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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKβ promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice

Fig. 1

Neuronal TNFR1 advances the onset of clinical symptoms and spinal cord inflammation in EAE. (A) Mean clinical scores for nTNFR1KO (n = 7) and TNFR1ff control (n = 7) mice after immunization with MOG/CFA/PTx. (B) Differential expression of myelin, neuronal, and immune genes relative to GusB in total mRNA isolates taken from nTNFR1KO and control spinal cords of non-immunized (non-EAE) and immunized mice at peak of EAE in the control group (peak) (non-EAE: control, n = 3 and nTNFR1KO, n = 4; peak EAE: control, n = 10 and nTNFR1KO, n = 3). (C) Mean clinical scores for nTNFR2KO (n = 10) and TNFR2ff control (n = 10) mice after immunization with MOG/CFA/PTx. Results shown are representative of two (A) or three (C) independent experiments and are presented as mean values ± SEM. Statistical significance after pairwise comparisons between measurements of EAE clinical scores between the KO and control mouse strains on each day (A, C) and mRNA levels (B) are shown by Student’s t-test. *p ≤ 0.05, **p ≤ 0.005, ***p ≤ 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094