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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation

Fig. 2

Increased vascular leakage from CNV in progranulin knockout mice. a Representative photographs of ocular fundus from Grn+/+, Grn+/−, and Grn−/− mice (9–12 weeks) immediately after laser coagulation. Angiographic images at 14 days after photocoagulation. b. Graph of the FFA grade scores of each laser spot (Grn+/+, 64 laser spots; Grn+/−, 75 laser spots; and Grn−/−, 57 laser spots). The comparison of each group was performed using the laser spots of all grades. Data are presented as percentages. *P <0.05 vs. Grn+/+, #P <0.05 vs. Grn+/− (Dunn-Bonferroni post hoc method following significant Kruskal-Wallis tests). c. Graph of the average leakage grade. (Grn+/+, n = 11; Grn+/, n = 13; and Grn−/−, n = 10). Data are the means ± SEMs. *P <0.05, vs. Grn+/+; #P <0.05, vs. Grn+/− (one-way ANOVA followed by Tukey’s test)

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