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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder

Fig. 7

Effect of inhibition of microglia activation on hippocampal neuron survival in Cdkl5 +/- mice. A Quantification of NeuN positive cells in CA1 layer of hippocampal sections from untreated Cdkl5 mice (+/+ n=3, +/- n=3) and 7-day luteolin-treated Cdkl5 +/- mice (+/- Lut7d, n=4). B Mean AIF-1-cell body size of microglial cells in the hippocampus of vehicle-treated 3-month-old Cdkl5 +/+ (n=5) and Cdkl5 +/- (n=6) mice and from Cdkl5 +/- mice injected with acetaminophen (APAP; i.p. 100 mg/Kg) every day for 7 days (n=4). C Quantification of NeuN positive cells in CA1 layer of hippocampal sections from mice treated as in B. D Mean AIF-1-cell body size of microglial cells in the hippocampus of vehicle-treated 3-month-old Cdkl5 +/+ (n=4) and Cdkl5 +/- (n=4) mice and from Cdkl5 +/- mice injected with Stattic (i.p. 20 mg/Kg), every other day for 7 days (n=4). E Quantification of NeuN positive cells in CA1 layer of hippocampal sections from mice treated as in D. The results in A–E are represented as means ± SEM. ***p<0.001 (Fisher’s LSD test after one-way ANOVA)

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