Fig. 8

Assessment of microglia activation in different life stages of Cdkl5 +/- mice. A, B Quantification of the number of AIF-1-positive cells (on the left) and mean AIF-1-cell body size (on the right) of microglial cells in somatosensory cortex (A) and hippocampal sections (B) from young (20-day-old; +/+ n=5; +/- n=6), adult (3-month-old; +/+ n=5; +/- n=6), and middle-aged (11-month-old; +/+ n=4; +/- n=4) Cdkl5 mice. The results in A and B are presented as means ± SEM. * p<0.05; ** p<0.01; ***p<0.001 (Fisher’s LSD test after two-way ANOVA)