Table 2 Detailed descriptions of the genes in the pathways related hypomethylated m6A and upregulated mRNA (M2-L vs M0-L)
From: The potential roles of m6A modification in regulating the inflammatory response in microglia
Gene symbol | Pathway | Gene symbol | Pathway |
|---|---|---|---|
Ndufs3 | Oxidative phosphorylation; Alzheimer disease; Parkinson disease; Huntington disease | Tyms | One carbon pool by folate; Pyrimidine metabolism |
Tusc3 | Protein processing in endoplasmic reticulum ; N-Glycan biosynthesis | Rpia | Carbon metabolism; Biosynthesis of amino acids |
Ch25h | Primary bile acid biosynthesis | Exosc8 | RNA degradation |
Pole2 | DNA replication; Nucleotide excision repair; Base excision repair | Sap18 | RNA transport; mRNA surveillance pathway |
Rps3a | Ribosome | Nup35 | RNA transport |
LOC103694506 | Ubiquitin mediated proteolysis | Rad51c | Homologous recombination |
Ube2a | Ubiquitin mediated proteolysis | Snrpd3 | Spliceosome |
Ero1a | Protein processing in endoplasmic reticulum | Srsf10 | Spliceosome |
Psat1 | Carbon metabolism; Biosynthesis of amino acids; Cysteine and methionine metabolism; Glycine, serine and threonine metabolism | Cdk7 | Cell cycle; Nucleotide excision repair; Basal transcription factors |
Ak6 | Ribosome biogenesis in eukaryotes; Purine metabolism | Tbp | Huntington disease; Basal transcription factors |
Lsm8 | Spliceosome; RNA degradation | Rpl15 | Ribosome |
Cycs | Parkinson disease; Huntington disease; Alzheimer disease; | Vkorc1l1 | Ubiquinone and other terpenoid-quinone biosynthesis |
Sec11c | Protein export | Rpl26 | Ribosome |
Rpa3 | DNA replication; nucleotide excision repair; mismatch repair; homologous recombination; | Prps1 | Carbon metabolism; Biosynthesis of amino acids |
Eif2s3y | RNA transport | Rbbp4 | Cellular senescence |
Nudt21 | mRNA surveillance pathway | C1d | RNA degradation; mitophagy |
Ssr1 | Protein processing in endoplasmic reticulum | Taf13 | Basal transcription factors |
Snrpb2 | Spliceosome | Psma3 | Proteasome |
Skp1 | Cell cycle; ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum | Polr2k | Huntington disease; RNA polymerase |
Ndufb11 | Oxidative phosphorylation; Parkinson disease; Huntington disease; Alzheimer disease; | Lsm5 | Spliceosome; RNA degradation |
Uqcrh | Oxidative phosphorylation; Alzheimer disease; Parkinson disease; Huntington disease; | Ppp3r1 | Alzheimer disease; Cellular senescence; |
Ppp2cb | mRNA surveillance pathway; autophagy; AMPK signaling pathway; Sphingolipid signaling pathway | Ndufb3 | Oxidative phosphorylation; Parkinson disease; Huntington disease; Alzheimer disease; |
Rps11 | Ribosome | Mrps21 | Ribosome |
Aasdhppt | Pantothenate and CoA biosynthesis | Thoc6 | RNA transport |
Mrpl35 | Ribosome | Bnip3 | Mitophagy; autophagy |
Mdh1 | Carbon metabolism; citrate cycle (TCA cycle); Glyoxylate and dicarboxylate metabolism; Cysteine and methionine metabolism | Ccnh | Cell cycle; Basal transcription factors; Nucleotide excision repair |
Exosc3 | RNA degradation | Â | Â |