Table 1 Analyzed behavioral parameters in the open field, NOR, NLR, and MWM (mean ± SEM). Open field behavior was characterized by total distance moved (distance) and the percentage of time in the center (time center). Total exploration of objects in phase 1 (2 similar objects), 2 (NOR), and 3 (NLR) of the NOR and NLR was determined. In the MWM, the area under the curve (AUC) for the training sessions (learning) and reversal training sessions (reversal), the time in the target quadrant (TQ) during the first (test 1) and second probe trial (test 2) and the distance moved (distance) were determined. C control, IBU ibuprofen. F statistics (F) are displayed for age (A), intervention (I), and age*intervention (A*I) effects. * p < 0.05

 Distance (cm)

3192 ± 115

3399 ± 80

2299 ± 124

2253 ± 129

78.6*

0.48

1.20

 Time center (%)

17 ± 3

17 ± 3

8 ± 2

7 ± 1

19.7*

0.18

0.09

NOR/NLR

 Object exploration 1 (%)

27 ± 1

22 ± 2

23 ± 2

20 ± 2

1.62

3.91

0.23

 Object exploration 2 (%)

16 ± 2

14 ± 2

10 ± 1

8 ± 3

8.35*

0.82

0.00

 Object exploration 3 (%)

16 ± 2

12 ± 2

10 ± 2

10 ± 2

4.36*

1.14

1.55

 Learning (AUC)

107 ± 10

104 ± 7

137 ± 9

124 ± 8

8.14*

0.80

0.31

 Reversal (AUC)

21 ± 2

25 ± 2

33 ± 3

32 ± 4

12.3*

0.34

0.54

 TQ Test 1 (%)

25 ± 2

23 ± 1

32 ± 2

27 ± 2

7.22*

3.09

0.91

 TQ Test 2 (%)

30 ± 2

34 ± 4

31 ± 2

29 ± 2

0.63

0.15

0.87

 Platform crossings test 1

1.9 ± 0.5

2.1 ± 0.2

2.8 ± 0.4

2.4 ± 0.5

1.75

0.02

0.60

 Platform crossings test 2

2.8 ± 0.2

3.4 ± 0.4

2.2 ± 0.4

2.3 ± 0.5

5.34*

1.16

0.37

 Distance test 1 (cm)

1144 ± 50

1256 ± 50

947 ± 70

1081 ± 47

10.4*

4.57*

0.03

 Distance test 2 (cm)

1105 ± 51

1203 ± 41

898 ± 75

1041 ± 50

10.2*

4.32*

0.15