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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

Fig. 5

GW9508 inhibited the activation of M1 microglia surrounding the hematoma at 24 h after GMH. Double immunofluorescence staining to detect the number of M1 microglia (CD16/CD11b) in sham (a), GMH (b), and GMH + GW9508 treatment groups (c). d The number of CD16- and CD11b-positive cells per field. The error bars represent the mean ± SD. n = 5 per group, three regions surrounding the hematoma (e) were analyzed in each rat. ***p < 0.001 vs sham, @@@p < 0.001 vs. GMH + vehicle. Note: peri-hematoma region is below the white broken line

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Journal of Neuroinflammation

ISSN: 1742-2094