Fig. 5
From: VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy
VMP1 depletion inhibits the progression of autophagic flux. A GSEA showed that genes in the VMP1 high group were enriched in pathways related to the regulation of autophagy and lysosomes. Correlation between VMP1 expression and autophagy-related genes, including ATG4A (B), ATG4C (C), ATG5 (D), ATG7 (E), ATG9B (F), ATG10 (G), and ATG12 (H). I, J RFP-GFP-LC3B dual-reporter assay showing the accumulation of autolysosomes. RFP-positive and GFP-negative dots indicate autolysosomes. K TEM microphotographs showing the ultrastructure of cells. Red arrows indicate endogenous autolysosomes