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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease

Fig. 6

Resident and infiltrating myeloid cells show spatial immunophenotypic heterogeneity in WNE. a Schematic showing the 5 anatomic regions dissected from the murine brain. b Heatmap showing the relative intensity of selected markers on/in unstained (uns.) cells and microglia in the olfactory bulb, frontal cortex, posterior cortex, pons/medulla and cerebellum in the homeostatic and WNV-infected brain. c tSNE plot clustered on live myeloid cells from all brain regions and overlaid with total myeloid cells found in each region: olfactory bulb, frontal cortex, posterior cortex, pons/medulla and cerebellum. d Histograms showing signal intensities of selected markers on Ly6Chi macrophages from 5 different brain regions in WNV dpi 7 brains. Unstained cells are represented by the shaded grey peak in each plot. Data shown in a-d is representative of one experiment with six brains pooled per brain region

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