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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

Fig. 3

SCDEs improved functional recovery after SCI in vivo. a Representative images of immunofluorescent analysis of neurotransmitter marker 5-HT (red), GFAP (green), and DAPI (blue) in each group at 4 weeks after SCI. White arrow showed the downstream distance of 5-HT+ axons. Scale bars = 200 μm. Right images are high-resolution versions of the boxed regions in the left images, scale bars = 50 µm. bd Quantitative analysis of 5-HT+ axon dieback (mm) and the intensity mean value of 5-HT and GFAP (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 6). e Quantitative analysis of BMS score between each group (**P < 0.01, n = 6). fi Quantitative analysis of catwalk at 8 weeks, including print length, stride length, and print area (*P < 0.05, ns: no significance, n = 6, LF: left front paw, RF: right front paw, RH: right hind paw)

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