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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

Fig. 6

Upregulated TLR2 expression on astrocytes induced by SCDEs was via NF-κB/PI3K signaling pathway. a Representative western blots showing the activation of NF-κB/PI3K signaling in vivo. b, c Quantitative analysis of the pPI3K/PI3K ratio and NF-κB/GAPDH ratio in PBS group mice after SCI, SCDEs group mice after SCI, and control mice without surgery (sham). d Representative western blots showing the activation of NF-κB/PI3K signaling in vitro. e, f Quantitative analysis of the pPI3K/PI3K ratio and NF-κB/GAPDH ratio in sham group astrocytes, PBS group astrocytes with H2O2 incubation, and SCDEs treated astrocytes with H2O2 incubation. g Representative western blots validating the activation of NF-κB/PI3K signaling. hj Quantitative analysis of the TLR2/GAPDH, CS56/GAPDH, and GFAP/GAPDH ratio in PBS group mice after SCI, SCDEs group mice after SCI, SCDEs and SC-514 group mice after SCI, and control mice without surgery (sham). (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 3)

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