Fig. 1

A Chemical structure and specific synthesis route of cel-p. B IC₅₀ values of cel and cel-p against living primary neurons. C, D Cel and cel-p showed similar neuroprotective effects in an OGD model of primary neurons in vitro. The optimal dose of cel and cel-p was 0.1–0.8 μM, and the optimal administration time was continuous administration for 48 h immediately after OGD. Cel-p closely mimicked the original compound in biological activity. Error bars represent SEM. ^###p < 0.001 vs. control group, *p < 0.05, **p < 0.01, ***p < 0.001 vs. model group based on a one-way analysis of variance (n = 6)