Skip to main content
Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Fig. 2

Cel significantly reduced the volume of cerebral infarction, improved the behavior indexes, and decreased Nissl staining injury of MCAO rats. A Representative brain slices stained by TTC. B Quantitative evaluation of infarct volume. C Zea-Longa score results indicated that cel and eda injection improved the behavior indexes of MCAO rats at 24 h, 48 h, and 72 h. D, E Compared with the sham group, extensive neuronal cell loss, nuclear shrinkage, and dark staining (at the red arrowhead) were visualized in the cortex of the model group. Administration of cel or eda markedly reduced these pathological changes. Error bars represent SEM. ###p < 0.001 vs. sham group, *p < 0.05, **p < 0.01, ***p < 0.001 vs. model group based on a one-way analysis of variance was used (n = 8, Nissl staining n = 3). Scale bar = 200 μm

Back to article page