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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

Fig. 6

A Secreted HMGB1 in the OGD model group supernatant medium evolved over time and reached a peak at 24 h. B Cel did not affect the level of secreted HMGB1 in supernatant medium 48 h after OGD injury. The disulfide form (not the fully reduced) HMGB1 isoform occupied the vast majority of HMGB1 isoforms in the OGD supernatant (C) and neuron cells (D), and cel did not affect the redox states of HMGB1. E Structure and function of HMGB1, a 25-kDa protein consisting of 214 amino acids

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