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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease

Fig. 3

Body weight gain in relation to the degree of nigrostriatal lesion and HOMA-IR. A Total body weight prior to and following the 6-OHDA toxin or vehicle administration in sham, moderate, and severe lesion groups fed with either CTRL diet or HFD. B Area under the curve (AUC) of body weight for 11 weeks post-lesion of mice fed with either CTRL diet or HFD in sham, moderate, and severe lesion groups. Data are expressed in (a.u). C Linear regression analysis between AUC of body weight and remaining TH+ cells or between D the HOMA-IR value and AUC of body weight in HFD group. E Histogram showing log HOMA-IR value in the sham, moderate, and severe lesion groups for CTRL diet and HFD. Sham (CTRL diet: n = 5, HFD: n = 4), moderate lesion (CTRL diet: n = 3, HFD: n = 3), severe lesion (CTRL diet: n = 6, HFD: n = 4). Two-way ANOVA (B, E): *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; linear regression analysis (C, D): **p < 0.01. HOMA-IR Homeostatic Model Assessment of Insulin Resistance, AUC area under the curve, a.u arbitrary unit

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