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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease

Fig. 5

HFD effect on striatal vessel density, branching points, and pericyte density. A Confocal images showing CD31+ vessel density (red) and B CD13+ pericyte density (cyan) in sham, moderate, and severe lesion groups fed with either CTRL diet or HFD. C Quantification of vessel density expressed in percentage of the total image area and D vessel branching points in all groups. E Quantification of CD31 density expressed in percentage of the total image area. F Histogram showing proportion of CD13+ pericyte density to CD31+ vessel density in percentage. Sham (CTRL diet: n = 5, HFD: n = 4), moderate lesion (CTRL diet: n = 3, HFD: n = 3), and severe lesion (CTRL diet: n = 6, HFD: n = 4). Two-way ANOVA: *p < 0.05, **p < 0.01, ***p < 0.001. Scale bar 50 μm

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