Fig. 8From: Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injuryProposed mechanisms of acute treatment of rA2 in protecting against TBI. rA2 binds to and reduces TLR4 on leukocyte surface, and attenuates TLR4/NFκB activation in leukocytes, and thereby inhibits leukocyte brain infiltration, neuroinflammation, and neuronal cell death, and ultimately improves neurological outcome after TBIBack to article page