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Table 2 Density and distribution of Iba1+/TMEM119+ microglial cells and infiltrating Iba1+/TMEM119 myeloid cells in both layers of the dorsal hippocampus CA1

From: Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice

Parameters Stratum radiatum Stratum lacunosum-moleculare
Day 0
Mean ± SEM
Day 7 p.i.
Mean ± SEM
Day 10 p.i.
Mean ± SEM
Day 0
Mean ± SEM
Day 7 p.i.
Mean ± SEM
Day 10 p.i.
Mean ± SEM
Iba1+/TMEM119+microglial cells
  Density (cells/mm2) 211.3 ± 4.8 206.2±20.4 218.0 ± 13.7 232.3 ± 11.0 220.9 ± 26.3 275.5 ± 23.8
  Spacing index (a.u.) 0.474 ± 0.007 0.453±0.013 0.480 ± 0.018 0.484 ± 0.016 0.477 ± 0.014 0.497 ± 0.010
  NND (μm) 47.75 ± 0.66 48.14±1.94 48.00 ± 1.49 45.80 ± 2.08 47.79 ± 3.04 43.97 ± 1.62
  Number of clusters per animal 0.000 ± 0.000 0.150±0.081 0.333 ± 0.109 0.000 ± 0.000 0.150 ± 0.081 0.333 ± 0.109
Infiltrating Iba1+/TMEM119-myeloid cells
  Density (cells/mm2) 0.6393 ± 0.5245 0.1873 ± 0.1186 1.030 ± 0.664 3.510 ± 1.469 2.454 ± 0.786 4.843 ± 1.808
  Ratio over Iba1+ cells (%) 0.2817 ± 0.2086 0.0940 ± 0.0604 0.4300 ± 0.2764 1.288 ± 0.510 1.102 ± 0.330 1.672 ± 0.458
  1. a.u., arbitrary unit; NND, nearest neighbor distance; p.i., post-infection; SEM, standard error of the mean
  2. Results are the mean ± SEM of 5–6 hippocampi per animal for a total of 5–6 mice per time point
  3. Statistical analyses were performed using a one-way analysis of variance with Tukey’s multiple comparisons test