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Table 5 Cellular localization of Zikaf virus antigens labeled with immunogold in both layers of the dorsal hippocampus CA1

From: Microglia are involved in phagocytosis and extracellular digestion during Zika virus encephalitis in young adult immunodeficient mice

Cell Types Number of cells with at least 2 nanogold particles (%)
Not treated with PLX5622 Treated with PLX5622
st rad st lac mol st rad st lac mol
 Neurons 2 (22.2) 3 (14.3) 10 (58.8) 4 (11.4)
 Astrocytes 3 (33.3) 5 (23.8) 4 (23.5) 28 (80.0)
 Oligodendrocytes 0 (0.0) 0 (0.0) 1 (5.9) 0 (0.0)
 Microglia 2 (22.2) 1 (4.8) 1 (5.9) 0 (0.0)
Parenchymal cells 7 (77.8) 9 (42.9) 16 (94.1) 32 (91.4)
 Endothelial cells 0 (0.0) 2 (9.5) 0 (0.0) 1 (2.9)
 Pericytes 0 (0.0) 5 (23.8) 1 (5.9) 0 (0.0)
 Other perivascular cells 2 (22.2) 5 (23.8) 0 (0.0) 2 (5.7)
Perivascular cells 2 (22.2) 12 (57.1) 1 (5.9) 3 (8.6)
Total cells 9 (100.0) 21 (100.0) 17 (100.0) 35 (100.0)
  1. % of a specific cell type to the total number of cells containing nanogold particles; st rad, stratum radiatum; st lac mol, stratum lacunosum-moleculare. In the st rad, 36 pictures (7–13 per animal) for untreated and 47 pictures (9–14 per animal) for treated mice were analyzed. In the st lac mol, 51 pictures (8–16 per animal) for untreated and 59 pictures (9–22 per animal) for treated mice were analyzed. n = 4 mice per group