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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy

Fig. 3

Glial reaction in the medial vestibular nuclei (VNs) are blocked by the acute anti-inflammatory treatment after UVN. A Confocal analysis of microglial cells immunostained with IBA1 and DAPI (nucleus) in the deafferented medial VNs of a representative animal in sham, UVN + placebo, and UVN + methylprednisolone (UVN + met) groups at d3 and d30 post-UVN. Scale bar, 50 mm. N = 4 animals per group. B Histograms showing the effects of vestibular lesion combined with placebo or acute anti-inflammatory treatment on the number of IBA1 immunoreactive cells in the deafferented medial VNs at d3 and d30 post-UVN. C Confocal analysis of astroglial cells immunostained with GFAP and DAPI (nucleus) in the deafferented medial VNs of a representative animal in sham, UVN + placebo, and UVN + met groups at d3 and d30 post-UVN. Scale bar, 50 mm. N = 4 animals per group. D Histograms showing the effects of vestibular lesion combined with placebo or acute anti-inflammatory treatment on the number of GFAP immunoreactive cells in the deafferented MVN at d3 and d30 post-UVN Each data point represents the mean number of immunoreactive cells, with error bars representing SEM. *p < 0.05; **p < 0.01; ***p < 0.001, 2 two-way ANOVA, post hoc Tukey: the sham and UVN + placebo comparison is indicated by a blue*; the sham and UVN + met comparison is indicated by a green*; and the UVN + placebo and UVN + met comparison is indicated by a red*

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