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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy

Fig. 8

Acute anti-inflammatory treatment exacerbates postural alteration and has no beneficial effects on locomotion after UVN. A Results representing changes in the mean body torsion, in degrees, along post-operative time for each group, normalized by subtracting the pre-operative value for each rat. Positives values indicate an increase in body torsion toward the left side while negative values indicate an increase towards the right side. B Results representing changes in the total distance moved along post-operative time for each group, normalized as a ratio of the pre-operative value. C Results representing changes in the mean velocity along post-operative time for each group, normalized as a ratio of the pre-operative value. D Results representing changes in the mean acceleration along post-operative time for each group, normalized as a ratio of the pre-operative value. A red box is applied on the curve to illustrate the acute time window of the vestibular syndrome (d1 to d3) where the treatments were administrated daily. Each data point represents the mean for each group with error bars representing SEM. *p < 0.05; **p < 0.01; ***p < 0.001, 2 two-way ANOVA, post hoc Tukey: the sham and UVN + placebo comparison is indicated by a blue*; the sham and UVN + met comparison is indicated by a green*; and the UVN + placebo and UVN + met comparison is indicated by a red*

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