Breaking a dogma: acute anti-inflammatory treatment alters both post-lesional functional recovery and endogenous adaptive plasticity mechanisms in a rodent model of acute peripheral vestibulopathy

Table 1 Post hoc multiple comparisons for UVN + placebo and UVN + met groups based on Tukey’s procedure for cellular and behavioral analyses

Analysis	Delay	Mean UVN + placebo	Mean UVN + met	SE of diff	q	DF	p value*
Cellular analyses
IBA1-ir cells	D3	46.8	8.33	5.86	9.28	67	< 0.0001***
IBA1-ir cells	D30	36.1	13.9	7.24	4.34	67	0.0085***
GFAP-ir cells	D3	49.6	16.1	4.5	10.5	63	< 0.0001***
GFAP-ir cells	D30	34.1	16	6.63	3.86	63	0.0219*
% GR/DAPI ir-cells	D3	65.3	44.8	8.08	3.58	56	0.0373*
BrdU-ir cells	D3	31.7	20.6	4.14	3.79	45	0.0271*
BrdU-ir cells	D30	29.9	2.13	3.95	9.95	45	< 0.0001***
KCC2 fluorescence intensity	D3	43.8	84	3.96	14.3	162	< 0.0001***
Behavioral analyses
Qualitative scale	D3	4.88	6.35	0.565	3.7	368	0.0251*
	D7	4	5.67	0.565	4.17	368	0.0095**
	D14	2.24	4.33	0.565	5.25	368	0.0007***
	D21	1.94	3.93	0.565	4.98	368	0.0014**
	D30	2.06	3.47	0.565	3.52	368	0.0352*
Support surface	D7	1.15	1.76	0.141	6.1	174	< 0.0001***
	D14	1.08	1.74	0.141	6.65	174	< 0.0001***
	D21	0.957	1.62	0.141	6.63	174	< 0.0001***
	D30	0.929	1.55	0.141	6.22	174	< 0.0001***
Left circling	D3	1.38	7.4	1.37	6.22	51	0.0002***
Left circling	D30	0.813	4.5	1.37	3.81	51	0.0255*
Weight distributed on the abdomen	D30	− 1.76	7.31	2.46	5.21	34	0.0022**
Evolution of the barycenter inertia	D30	1.29	3.81	0.868	4.1	38	0.0166*
Evolution of the barycenter’s lateral maximum deviation	D30	1.13	1.78	0.261	3.54	38	0.0432*
Mean body torsion	D1	5.56	11.5	2.1	3.97	248	0.0148*
Mean body torsion	D2	3.73	8.99	2.1	3.55	248	0.0340*

Table summarizing the significant statistical differences observed between the UVN + placebo and the UVN + met groups for cellular and behavioral analyses during Tukey’s post hoc multiple comparisons test. SE of diff standard error for the difference between two means, q q ratio for Tukey’s post hoc multiple comparisons test, p probability level, DF degree of freedom, p < 0.05; **p < 0.01, ***p < 0.001

ISSN: 1742-2094