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Table 2 Odds ratios (95% confidenceintervals) for leukocyte subtypes and poor functional outcome (mRS 4–6)

From: CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

   All patients Saline Alteplase
30 days Cell type# N OR (95% CI)* P N OR (95% CI) P N OR (95% CI) P
Serum WBC 375 1.03 (0.93–1.13) 0.620 184 1.08 (0.93–1.25) 0.292 191 0.98 (0.87–1.10) 0.727
Neutrophils‡ 245 1.01 (0.99–1.02) 0.549 129 1.00 (0.98–1.03) 0.787 116 1.01 (0.98–1.03) 0.574
Monocytes‡ 248 0.95 (0.83–1.08) 0.420 129 0.93 (0.76–1.15) 0.509 119 0.97 (0.82–1.15) 0.697
Lymphocytes‡ 248 0.97 (0.91–1.04) 0.443 129 1.00 (0.91–1.10) 0.983 119 0.95 (0.86–1.05) 0.282
NLR 245 1.09 (0.94–1.25) 0.259 129 1.03 (0.85–1.24) 0.767 116 1.17 (0.92–1.49) 0.212
CSF WBC‡ 140 1.12 (0.81–1.54) 0.478 62 1.80 (0.56–5.73) 0.323 78 1.07 (0.78–1.47) 0.673
Neutrophils‡ 131 1.10 (0.77–1.56) 0.610 55 1.57 (0.57–4.32) 0.380 76 1.05 (0.79–1.39) 0.729
Monocytes 118 1.01 (0.98–1.04) 0.512 52 1.08 (0.93–1.26) 0.304 66 1.01 (0.98–1.03) 0.689
Lymphocytes 116 1.19 (0.28–5.19) 0.812 48 1.75 (0.99–2.80) 0.081 68 1.04 (0.99–1.10) 0.108
NLR 86 0.96 (0.88–1.05) 0.352 36 0.88 (0.73–1.05) 0.142 50 0.98 (0.88–1.10) 0.748
180 days Cell type N OR (95% CI) P N OR (95% CI) P N OR (95% CI) P
Serum WBC 317 1.01 (0.91–1.11) 0.872 148 1.05 (0.90–1.22) 0.510 169 0.98 (0.88–1.10) 0.775
Neutrophils‡ 208 1.01 (0.99–1.02) 0.321 106 1.00 (0.98–1.02) 0.915 102 1.02 (0.99–1.04) 0.254
Monocytes‡ 209 0.96 (0.85–1.07) 0.452 106 0.97 (0.82–1.14) 0.693 103 0.96 (0.82–1.12) 0.575
Lymphocytes‡ 210 0.94 (0.89–0.99) 0.047 106 0.87 (0.80–0.95) 0.002 104 1.06 (0.97–1.16) 0.233
NLR 208 1.13 (1.00–1.28) 0.042 106 1.31 (1.10–1.56) 0.003 102 1.00 (0.83–1.19) 0.966
CSF WBC‡ 114 1.04 (0.97–1.10) 0.275 47 0.92 (0.63–1.33) 0.652 67 1.05 (0.96–1.15) 0.303
Neutrophils‡ 108 1.16 (0.96–1.40) 0.113 42 1.19 (0.54–2.63) 0.669 66 1.15 (0.96–1.37) 0.123
Monocytes 96 1.00 (0.98–1.02) 0.737 40 0.99 (0.97–1.02) 0.663 56 1.00 (0.98–1.03) 0.775
Lymphocytes 94 1.01 (0.98–1.03) 0.483 36 1.01 (0.96–1.06) 0.600 58 1.01 (0.98–1.03) 0.550
NLR 71 0.99 (0.93–1.07) 0.880 28 0.98 (0.86–1.10) 0.700 43 1.02 (0.94–1.12) 0.599
  1. CSF indicates cerebrospinal fluid; mRS, modified Rankin Scale; NLR, neutrophil-to-lymphocyte ratio; OR, odds ratio; and WBC, white blood cells
  2. *All ORs are adjusted for severity index and percent IVH clearance
  3. Median cell counts are from ≥3 daily counts
  4. Median/100
  5. #Cell counts are in units of cells per μL