CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

Gusdon, Aaron M.; Thompson, Carol B.; Quirk, Kendel; Mayasi, Yunis M.; Avadhani, Radhika; Awad, Issam A.; Hanley, Daniel F.; Ziai, Wendy C.

doi:10.1186/s12974-021-02224-w

Journal of Neuroinflammation

Table 2 Odds ratios (95% confidenceintervals) for leukocyte subtypes and poor functional outcome (mRS 4–6)

From: CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

		All patients			Saline			Alteplase
30 days	Cell type^#	N	OR (95% CI)*	P	N^†	OR (95% CI)	P	N	OR (95% CI)	P
Serum	WBC	375	1.03 (0.93–1.13)	0.620	184	1.08 (0.93–1.25)	0.292	191	0.98 (0.87–1.10)	0.727
	Neutrophils‡	245	1.01 (0.99–1.02)	0.549	129	1.00 (0.98–1.03)	0.787	116	1.01 (0.98–1.03)	0.574
	Monocytes‡	248	0.95 (0.83–1.08)	0.420	129	0.93 (0.76–1.15)	0.509	119	0.97 (0.82–1.15)	0.697
	Lymphocytes‡	248	0.97 (0.91–1.04)	0.443	129	1.00 (0.91–1.10)	0.983	119	0.95 (0.86–1.05)	0.282
	NLR	245	1.09 (0.94–1.25)	0.259	129	1.03 (0.85–1.24)	0.767	116	1.17 (0.92–1.49)	0.212
CSF	WBC‡	140	1.12 (0.81–1.54)	0.478	62	1.80 (0.56–5.73)	0.323	78	1.07 (0.78–1.47)	0.673
	Neutrophils‡	131	1.10 (0.77–1.56)	0.610	55	1.57 (0.57–4.32)	0.380	76	1.05 (0.79–1.39)	0.729
	Monocytes	118	1.01 (0.98–1.04)	0.512	52	1.08 (0.93–1.26)	0.304	66	1.01 (0.98–1.03)	0.689
	Lymphocytes	116	1.19 (0.28–5.19)	0.812	48	1.75 (0.99–2.80)	0.081	68	1.04 (0.99–1.10)	0.108
	NLR	86	0.96 (0.88–1.05)	0.352	36	0.88 (0.73–1.05)	0.142	50	0.98 (0.88–1.10)	0.748
180 days	Cell type	N	OR (95% CI)	P	N	OR (95% CI)	P	N	OR (95% CI)	P
Serum	WBC	317	1.01 (0.91–1.11)	0.872	148	1.05 (0.90–1.22)	0.510	169	0.98 (0.88–1.10)	0.775
	Neutrophils‡	208	1.01 (0.99–1.02)	0.321	106	1.00 (0.98–1.02)	0.915	102	1.02 (0.99–1.04)	0.254
	Monocytes‡	209	0.96 (0.85–1.07)	0.452	106	0.97 (0.82–1.14)	0.693	103	0.96 (0.82–1.12)	0.575
	Lymphocytes‡	210	0.94 (0.89–0.99)	0.047	106	0.87 (0.80–0.95)	0.002	104	1.06 (0.97–1.16)	0.233
	NLR	208	1.13 (1.00–1.28)	0.042	106	1.31 (1.10–1.56)	0.003	102	1.00 (0.83–1.19)	0.966
CSF	WBC‡	114	1.04 (0.97–1.10)	0.275	47	0.92 (0.63–1.33)	0.652	67	1.05 (0.96–1.15)	0.303
	Neutrophils‡	108	1.16 (0.96–1.40)	0.113	42	1.19 (0.54–2.63)	0.669	66	1.15 (0.96–1.37)	0.123
	Monocytes	96	1.00 (0.98–1.02)	0.737	40	0.99 (0.97–1.02)	0.663	56	1.00 (0.98–1.03)	0.775
	Lymphocytes	94	1.01 (0.98–1.03)	0.483	36	1.01 (0.96–1.06)	0.600	58	1.01 (0.98–1.03)	0.550
	NLR	71	0.99 (0.93–1.07)	0.880	28	0.98 (0.86–1.10)	0.700	43	1.02 (0.94–1.12)	0.599

CSF indicates cerebrospinal fluid; mRS, modified Rankin Scale; NLR, neutrophil-to-lymphocyte ratio; OR, odds ratio; and WBC, white blood cells
_*All ORs are adjusted for severity index and percent IVH clearance
_†Median cell counts are from ≥3 daily counts
_‡Median/100
_#Cell counts are in units of cells per μL

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ISSN: 1742-2094

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