Skip to main content

Table 2 Odds ratios (95% confidenceintervals) for leukocyte subtypes and poor functional outcome (mRS 4–6)

From: CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial

  

All patients

Saline

Alteplase

30 days

Cell type#

N

OR (95% CI)*

P

N

OR (95% CI)

P

N

OR (95% CI)

P

Serum

WBC

375

1.03 (0.93–1.13)

0.620

184

1.08 (0.93–1.25)

0.292

191

0.98 (0.87–1.10)

0.727

Neutrophils‡

245

1.01 (0.99–1.02)

0.549

129

1.00 (0.98–1.03)

0.787

116

1.01 (0.98–1.03)

0.574

Monocytes‡

248

0.95 (0.83–1.08)

0.420

129

0.93 (0.76–1.15)

0.509

119

0.97 (0.82–1.15)

0.697

Lymphocytes‡

248

0.97 (0.91–1.04)

0.443

129

1.00 (0.91–1.10)

0.983

119

0.95 (0.86–1.05)

0.282

NLR

245

1.09 (0.94–1.25)

0.259

129

1.03 (0.85–1.24)

0.767

116

1.17 (0.92–1.49)

0.212

CSF

WBC‡

140

1.12 (0.81–1.54)

0.478

62

1.80 (0.56–5.73)

0.323

78

1.07 (0.78–1.47)

0.673

Neutrophils‡

131

1.10 (0.77–1.56)

0.610

55

1.57 (0.57–4.32)

0.380

76

1.05 (0.79–1.39)

0.729

Monocytes

118

1.01 (0.98–1.04)

0.512

52

1.08 (0.93–1.26)

0.304

66

1.01 (0.98–1.03)

0.689

Lymphocytes

116

1.19 (0.28–5.19)

0.812

48

1.75 (0.99–2.80)

0.081

68

1.04 (0.99–1.10)

0.108

NLR

86

0.96 (0.88–1.05)

0.352

36

0.88 (0.73–1.05)

0.142

50

0.98 (0.88–1.10)

0.748

180 days

Cell type

N

OR (95% CI)

P

N

OR (95% CI)

P

N

OR (95% CI)

P

Serum

WBC

317

1.01 (0.91–1.11)

0.872

148

1.05 (0.90–1.22)

0.510

169

0.98 (0.88–1.10)

0.775

Neutrophils‡

208

1.01 (0.99–1.02)

0.321

106

1.00 (0.98–1.02)

0.915

102

1.02 (0.99–1.04)

0.254

Monocytes‡

209

0.96 (0.85–1.07)

0.452

106

0.97 (0.82–1.14)

0.693

103

0.96 (0.82–1.12)

0.575

Lymphocytes‡

210

0.94 (0.89–0.99)

0.047

106

0.87 (0.80–0.95)

0.002

104

1.06 (0.97–1.16)

0.233

NLR

208

1.13 (1.00–1.28)

0.042

106

1.31 (1.10–1.56)

0.003

102

1.00 (0.83–1.19)

0.966

CSF

WBC‡

114

1.04 (0.97–1.10)

0.275

47

0.92 (0.63–1.33)

0.652

67

1.05 (0.96–1.15)

0.303

Neutrophils‡

108

1.16 (0.96–1.40)

0.113

42

1.19 (0.54–2.63)

0.669

66

1.15 (0.96–1.37)

0.123

Monocytes

96

1.00 (0.98–1.02)

0.737

40

0.99 (0.97–1.02)

0.663

56

1.00 (0.98–1.03)

0.775

Lymphocytes

94

1.01 (0.98–1.03)

0.483

36

1.01 (0.96–1.06)

0.600

58

1.01 (0.98–1.03)

0.550

NLR

71

0.99 (0.93–1.07)

0.880

28

0.98 (0.86–1.10)

0.700

43

1.02 (0.94–1.12)

0.599

  1. CSF indicates cerebrospinal fluid; mRS, modified Rankin Scale; NLR, neutrophil-to-lymphocyte ratio; OR, odds ratio; and WBC, white blood cells
  2. *All ORs are adjusted for severity index and percent IVH clearance
  3. Median cell counts are from ≥3 daily counts
  4. Median/100
  5. #Cell counts are in units of cells per μL