Fig. 2

TAK1 inhibition improves neurological functions and attenuates brain edema 24h after SAH. a Modified Garcia score, b Beam balance test, and c brain water content in Sham, SAH+Vehicle, SAH+OZ (1 μg), and SAH+OZ (3 μg) groups at 24 h after SAH. d, e FJC staining and IgG staining in the ipsilateral cortex with quantification. f Immunoanalysis of tight junction proteins (ZO-1 and Occludin) in brain extracts of the indicated groups. The right panels show the quantification of the proteins. In a and b, n = 16 for each group. In c, n = 6 for each group. In d and f, n = 5 in each group. Data are expressed as mean ± SD. ***P < 0.001 vs Sham group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs SAH+Vehicle group. Scale bar: 20 μm