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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

Fig. 1

CatH deficiency prevents neuronal damage in hippocampus of neonatal mice 72 h after HI injury. A The histological changes in the hippocampus of WT and CatH−/− mice72 h after HI injury indicated with HE staining. Scale bar, 400 μm. B The quantification of the ipsi hippocampal area loss of WT (n = 25) and CatH−/− (n = 13) mice 72 h after HI injury. The asterisks indicate a statistically significant difference from the WT ipsi value (***p < 0.001, Student’s t tests). C Fluorescent CLSM images of the hippocampal region of WT and CatH−/− mice 72 h after HI injury. Scale bar, 50 μm. D The quantification of the ratio of pyknotic neuronal cells in the hippocampal CA1 region of WT and CatH−/− mice 72 h after HI injury. The columns and bars represent the mean ± SD (n = 6). The asterisks indicate a statistically significant difference from the indicated contra value (***p < 0.001, one-way ANOVA test). Contra contralateral, ipsi ipsilateral

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