Fig. 3

Chromatin accessibility in the rat DRG. A Principal component analysis plot of all ATAC-seq biological replicates for each of the 3 groups. Percent of variance each component explained is included in axis labels. B UpSet plot that shows the overlap of accessible regions among the 3 groups. C Distance of accessible regions from nearest gene. The distribution of accessible regions shows concentration in cis-regulatory regions (i.e., gene promoter, intergenic/enhancer) versus uniform/random distribution along the genome. ATAC-seq assay for transposase-accessible chromatin with high-throughput sequencing, CCI chronic constriction injury, CFA complete Freund’s adjuvant, TSS transcription start site