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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Repeated neonatal sevoflurane induced neurocognitive impairment through NF-κB-mediated pyroptosis

Fig. 3

BAY 11-7082 attenuates sevoflurane-induced pyroptosis and neuroinflammation in the rat hippocampus. A Representative western blotting and quantitative analysis of protein levels of GSDMD, GSDMD-N, IL-1β, and IL-18 in the hippocampus in developing rats. B ELISA analysis of IL-1β and IL-18 levels. C Representative images of GSDMD staining in the hippocampal CA1 and DG regions. Scale bar = 100 μm for all photographs except for the last one (scale bar = 50 μm). The lower panel shows the number of GSDMD-positive cells in the CA1 and DG regions of the hippocampus in the four experimental groups. Values are presented as mean ± SEM (n = 6 rats/group). *p < 0.05 versus the Con group; #p < 0.05 versus the Sev group

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