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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

Fig. 6

Inhibition of NHE1 protein with its inhibitor HOE642 in BCAS mice attenuated hippocampal astrogliosis. a Representative overview of NHE1 protein (green) and GFAP protein (red) expression in hippocampus at 30 days post-surgery. Thin arrow: increased GFAP+ astrocytes in CC and EC. Thick arrow: reactive GFAP+ astrocytes in hippocampus. Magnification ×10, scale bar = 400 μm. b Representative images of NHE1 (green) and GFAP (red) staining in stratum radiatum (SR) under CA1 field of hippocampus and in polymorph layer (PL) of dentate gyrus at 30 days post-surgery. Magnification ×40, scale bar = 50 μm. c Quantitative analysis of GFAP+ cells. Data are presented as mean ± SD. n = 5–6/group. *p < 0.05

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