Fig. 9

HOE642 treatment attenuated astrocytic NOX2 activation and LCN2 expression in white matter. a Representative staining images of phosphorylated p47 phox (green) and GFAP (red) in CC and EC at 30 days post-surgery. Magnification ×40, Scale bar = 25 μm. b Representative immunostaining images of LCN2 (green) and GFAP (red) in CC and EC. Magnification ×40, scale bar = 25 μm. c Quantitative analysis of the co-labeled p-p47⁺/GFAP⁺ cells in CC and EC. d Quantitative analysis of the co-labeled LCN2⁺/GFAP⁺ cells in CC and EC. All data are presented as mean ± SD. n = 5–6. **p < 0.01, ***p < 0.001, ****p < 0.0001