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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

Fig. 3

TNF-α voltage-dependently increases Na+ current density in RGCs. a Micrograph showing a typical acutely isolated RGC for recording. b Representative traces show Na+ currents recorded in acutely isolated RGCs from control (Ctr) and TNF-α7D retinas. The holding potentials of RGCs were set at −70 mV and the currents were evoked in the range of −70 to +30 mV with steps of 10 mV. c Current-voltage relationship curves of Na+ currents in RGCs of Ctr and TNF-α7D retinas. n = 11 and 14 for Ctr and TNF-α7D groups, respectively. d Summary data show the peak current densities of Na+ channels at −30 mV in RGCs of Ctr and TNF-α7D retinas. n = 11 and 14 for Ctr and TNF-α7D groups, respectively. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. Ctr

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