Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma

Fig. 7

TNF-α selectively upregulates Nav1.6 currents in rat RGCs. a Representative current traces recorded from an RGC show the changes of peak Nav1.6 currents before and after TNF-α application in the presence of the Nav1.1 blocker ICA12142 (1 μM) and the Nav1.2 blocker Phrixotoxin3 (10 nM). b Bar charts summarize the changes of Nav1.6 current amplitudes at −20 mV before and after TNF-α perfusion. Note that TNF-α enhanced Nav1.6 peak currents. n = 9. ***P < 0.001 vs. Ctr. c Representative traces show the changes in Nav1.1 and Nav1.2 mixed currents recorded in an RGC before and after TNF-α application in the presence of the Nav1.6 blocker AHTTX (100 nM). d Bar charts summarize the changes of mixed Nav1.1 and Nav1.2 current amplitudes before and after TNF-α application. n = 7

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094