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Table 2 Arterial pH, blood gases, glucose and lactate concentrations. Data are mean ± SE

From: Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep

  D1 base D1+2 h D1+6 h D2 base D2+2 h D2+6 h D3 base D3+2 h D3+6 h D4 base D5 base
pH
 Saline 7.38 ± 0.01 7.38 ± 0.01 7.38 ± 0.01 7.37 ± 0.01 7.38 ± 0.01 7.38 ± 0.01 7.38 ± 0.01 7.38 ± 0.01 7.37 ± 0.01 7.37 ± 0.01 7.36 ± 0.01
 LPS 7.36 ± 0.01 7.32 ± 0.01* 7.34 ± 0.01* 7.35 ± 0.01*# 7.33 ± 0.01* 7.35 ± 0.01* 7.34 ± 0.01* 7.33 ± 0.01* 7.34 ± 0.01* 7.32 ± 0.01* 7.34 ± 0.01
 LPS+IL-1Ra 7.38 ± 0.01 7.33 ± 0.01* 7.36 ± 0.01 7.38 ± 0.01 7.34 ± 0.01* 7.37 ± 0.01 7.36 ± 0.01 7.34 ± 0.01* 7.35 ± 0.01 7.35 ± 0.01 7.36 ± 0.01
PaCO2
 Saline 46.6 ± 1.0 45.4 ± 1.0 46.2 ± 1.0 47.2 ± 1.0 46.9 ± 1.4 46.0 ± 1.1 47.4 ± 0.6 46.7 ± 0.8 46.9 ± 1.2 48.0 ± 1.0 47.7 ± 1.1
 LPS 49.1 ± 0.4 49.7 ± 1.0* 51.5 ± 1.2* 49.4 ± 0.8 51.7 ± 0.9* 50.7 ± 0.9* 47.7 ± 0.9 48.5 ± 1.2 48.5 ± 0.6 46.0 ± 1.3 48.4 ± 1.0
 LPS+ IL-1Ra 47.0 ± 1.2 48.5 ± 1.4 49.6 ± 1.0* 49.3 ± 0.8 50.2 ± 1.0* 50.8 ± 1.1* 48.8 ± 0.8 48.3 ± 1.0 48.4 ± 0.7 48.1 ± 1.2 49.2 ± 0.7
PaO2
 Saline 23.9 ± 1.2 23.8 ± 0.9 23.3 ± 1.5 24.2 ± 1.1 23.6 ± 0.8 25.2 ± 0.9 22.5 ± 1.5 24.3 ± 1.1 24.0 ± 1.4 24.2 ± 1.3 23.9 ± 0.8
 LPS 22.1 ± 1.0 22.8 ± 0.8 19.2 ± 0.6* 22.9 ± 1.2 21.1 ± 1.2 20.1 ± 1.3* 22.8 ± 1.1 21.6 ± 1.3 20.8 ± 0.6* 23.5 ± 1.4 23.1 ± 0.7
 LPS+ IL-1Ra 21.3 ± 0.5 20.0 ± 0.6* 17.8 ± 0.3* 19.3 ± 0.9* 17.8 ± 1.2* 16.7 ± 1.0* 20.8 ± 0.9 19.0 ± 1.0 18.3 ± 0.7* 20.7 ± 1.0 21.2 ± 1.0
sO2
 Saline 66 ± 2 68 ± 2 65 ± 3 65 ± 2 66 ± 2 69 ± 2 64 ± 3 68 ± 2 66 ± 2 65 ± 2 65 ± 2
 LPS 62 ± 3 59 ± 3* 47 ± 2* 59 ± 3 50 ± 4* 48 ± 4* 61 ± 3 56 ± 3* 57 ± 2* 65 ± 2 65 ± 3
 LPS+ IL-1Ra 64 ± 1 57 ± 3* 51 ± 2* 56 ± 3 50 ± 4* 48 ± 3* 62 ± 2 55 ± 3* 53 ± 2* 63 ± 3 61 ± 2
Glucose
 Saline 0.9 ± 0.0 0.9 ± 0.0 0.9 ± 0.0 0.9 ± 0.0 0.9 ± 0.0 0.9 ± 0.0 0.9 ± 0.1 0.9 ± 0.1 0.9 ± 0.1 0.9 ± 0.0 0.9 ± 0.0
 LPS 0.9 ± 0.1 1.1 ± 0.1 0.8 ± 0.1 0.9 ± 0.0 0.8 ± 0.0 0.9 ± 0.2 1.0 ± 0.1 0.9 ± 0.1 1.0 ± 0.0 1.1 ± 0.2 0.9 ± 0.1
 LPS+ IL-1Ra 0.9 ± 0.1 0.9 ± 0.1 0.8 ± 0.1 0.9 ± 0.1 0.8 ± 0.1 0.9 ± 0.1 1.0 ± 0.1 0.8 ± 0.1 1.0 ± 0.1 0.9 ± 0.1 0.9 ± 0.1
Lactate
 Saline 1.7 ± 0.2 1.5 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 1.5 ± 0.1 1.5 ± 0.2 1.5 ± 0.1 1.4 ± 0.1 1.5 ± 0.1
 LPS 1.7 ± 0.1 3.1 ± 0.3* 4.0 ± 0.4* 1.5 ± 0.1 2.3 ±0.1* 1.9 ± 0.2 1.2 ± 0.1 1.3 ± 0.1 1.3 ± 0.1 1.1 ± 0.1 1.1 ± 0.1
 LPS+ IL-1Ra 1.6 ± 0.1 2.9 ± 0.4* 4.4 ± 0.9* 1.5 ± 0.2 2.1 ± 0.4 2.1 ± 0.4 1.2 ± 0.1 1.5 ± 0.1 1.3 ± 0.1 1.1 ± 0.1 1.2 ± 0.1
  1. *P < 0.05 vs. control