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Table 2 Arterial pH, blood gases, glucose and lactate concentrations. Data are mean ± SE

From: Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep

 

D1 base

D1+2 h

D1+6 h

D2 base

D2+2 h

D2+6 h

D3 base

D3+2 h

D3+6 h

D4 base

D5 base

pH

 Saline

7.38 ± 0.01

7.38 ± 0.01

7.38 ± 0.01

7.37 ± 0.01

7.38 ± 0.01

7.38 ± 0.01

7.38 ± 0.01

7.38 ± 0.01

7.37 ± 0.01

7.37 ± 0.01

7.36 ± 0.01

 LPS

7.36 ± 0.01

7.32 ± 0.01*

7.34 ± 0.01*

7.35 ± 0.01*#

7.33 ± 0.01*

7.35 ± 0.01*

7.34 ± 0.01*

7.33 ± 0.01*

7.34 ± 0.01*

7.32 ± 0.01*

7.34 ± 0.01

 LPS+IL-1Ra

7.38 ± 0.01

7.33 ± 0.01*

7.36 ± 0.01

7.38 ± 0.01

7.34 ± 0.01*

7.37 ± 0.01

7.36 ± 0.01

7.34 ± 0.01*

7.35 ± 0.01

7.35 ± 0.01

7.36 ± 0.01

PaCO2

 Saline

46.6 ± 1.0

45.4 ± 1.0

46.2 ± 1.0

47.2 ± 1.0

46.9 ± 1.4

46.0 ± 1.1

47.4 ± 0.6

46.7 ± 0.8

46.9 ± 1.2

48.0 ± 1.0

47.7 ± 1.1

 LPS

49.1 ± 0.4

49.7 ± 1.0*

51.5 ± 1.2*

49.4 ± 0.8

51.7 ± 0.9*

50.7 ± 0.9*

47.7 ± 0.9

48.5 ± 1.2

48.5 ± 0.6

46.0 ± 1.3

48.4 ± 1.0

 LPS+ IL-1Ra

47.0 ± 1.2

48.5 ± 1.4

49.6 ± 1.0*

49.3 ± 0.8

50.2 ± 1.0*

50.8 ± 1.1*

48.8 ± 0.8

48.3 ± 1.0

48.4 ± 0.7

48.1 ± 1.2

49.2 ± 0.7

PaO2

 Saline

23.9 ± 1.2

23.8 ± 0.9

23.3 ± 1.5

24.2 ± 1.1

23.6 ± 0.8

25.2 ± 0.9

22.5 ± 1.5

24.3 ± 1.1

24.0 ± 1.4

24.2 ± 1.3

23.9 ± 0.8

 LPS

22.1 ± 1.0

22.8 ± 0.8

19.2 ± 0.6*

22.9 ± 1.2

21.1 ± 1.2

20.1 ± 1.3*

22.8 ± 1.1

21.6 ± 1.3

20.8 ± 0.6*

23.5 ± 1.4

23.1 ± 0.7

 LPS+ IL-1Ra

21.3 ± 0.5

20.0 ± 0.6*

17.8 ± 0.3*

19.3 ± 0.9*

17.8 ± 1.2*

16.7 ± 1.0*

20.8 ± 0.9

19.0 ± 1.0

18.3 ± 0.7*

20.7 ± 1.0

21.2 ± 1.0

sO2

 Saline

66 ± 2

68 ± 2

65 ± 3

65 ± 2

66 ± 2

69 ± 2

64 ± 3

68 ± 2

66 ± 2

65 ± 2

65 ± 2

 LPS

62 ± 3

59 ± 3*

47 ± 2*

59 ± 3

50 ± 4*

48 ± 4*

61 ± 3

56 ± 3*

57 ± 2*

65 ± 2

65 ± 3

 LPS+ IL-1Ra

64 ± 1

57 ± 3*

51 ± 2*

56 ± 3

50 ± 4*

48 ± 3*

62 ± 2

55 ± 3*

53 ± 2*

63 ± 3

61 ± 2

Glucose

 Saline

0.9 ± 0.0

0.9 ± 0.0

0.9 ± 0.0

0.9 ± 0.0

0.9 ± 0.0

0.9 ± 0.0

0.9 ± 0.1

0.9 ± 0.1

0.9 ± 0.1

0.9 ± 0.0

0.9 ± 0.0

 LPS

0.9 ± 0.1

1.1 ± 0.1

0.8 ± 0.1

0.9 ± 0.0

0.8 ± 0.0

0.9 ± 0.2

1.0 ± 0.1

0.9 ± 0.1

1.0 ± 0.0

1.1 ± 0.2

0.9 ± 0.1

 LPS+ IL-1Ra

0.9 ± 0.1

0.9 ± 0.1

0.8 ± 0.1

0.9 ± 0.1

0.8 ± 0.1

0.9 ± 0.1

1.0 ± 0.1

0.8 ± 0.1

1.0 ± 0.1

0.9 ± 0.1

0.9 ± 0.1

Lactate

 Saline

1.7 ± 0.2

1.5 ± 0.1

1.5 ± 0.1

1.5 ± 0.1

1.5 ± 0.1

1.5 ± 0.1

1.5 ± 0.1

1.5 ± 0.2

1.5 ± 0.1

1.4 ± 0.1

1.5 ± 0.1

 LPS

1.7 ± 0.1

3.1 ± 0.3*

4.0 ± 0.4*

1.5 ± 0.1

2.3 ±0.1*

1.9 ± 0.2

1.2 ± 0.1

1.3 ± 0.1

1.3 ± 0.1

1.1 ± 0.1

1.1 ± 0.1

 LPS+ IL-1Ra

1.6 ± 0.1

2.9 ± 0.4*

4.4 ± 0.9*

1.5 ± 0.2

2.1 ± 0.4

2.1 ± 0.4

1.2 ± 0.1

1.5 ± 0.1

1.3 ± 0.1

1.1 ± 0.1

1.2 ± 0.1

  1. *P < 0.05 vs. control