| D1 base | D1+2 h | D1+6 h | D2 base | D2+2 h | D2+6 h | D3 base | D3+2 h | D3+6 h | D4 base | D5 base |
---|---|---|---|---|---|---|---|---|---|---|---|
pH | |||||||||||
 Saline | 7.38 ± 0.01 | 7.38 ± 0.01 | 7.38 ± 0.01 | 7.37 ± 0.01 | 7.38 ± 0.01 | 7.38 ± 0.01 | 7.38 ± 0.01 | 7.38 ± 0.01 | 7.37 ± 0.01 | 7.37 ± 0.01 | 7.36 ± 0.01 |
 LPS | 7.36 ± 0.01 | 7.32 ± 0.01* | 7.34 ± 0.01* | 7.35 ± 0.01*# | 7.33 ± 0.01* | 7.35 ± 0.01* | 7.34 ± 0.01* | 7.33 ± 0.01* | 7.34 ± 0.01* | 7.32 ± 0.01* | 7.34 ± 0.01 |
 LPS+IL-1Ra | 7.38 ± 0.01 | 7.33 ± 0.01* | 7.36 ± 0.01 | 7.38 ± 0.01 | 7.34 ± 0.01* | 7.37 ± 0.01 | 7.36 ± 0.01 | 7.34 ± 0.01* | 7.35 ± 0.01 | 7.35 ± 0.01 | 7.36 ± 0.01 |
PaCO2 | |||||||||||
 Saline | 46.6 ± 1.0 | 45.4 ± 1.0 | 46.2 ± 1.0 | 47.2 ± 1.0 | 46.9 ± 1.4 | 46.0 ± 1.1 | 47.4 ± 0.6 | 46.7 ± 0.8 | 46.9 ± 1.2 | 48.0 ± 1.0 | 47.7 ± 1.1 |
 LPS | 49.1 ± 0.4 | 49.7 ± 1.0* | 51.5 ± 1.2* | 49.4 ± 0.8 | 51.7 ± 0.9* | 50.7 ± 0.9* | 47.7 ± 0.9 | 48.5 ± 1.2 | 48.5 ± 0.6 | 46.0 ± 1.3 | 48.4 ± 1.0 |
 LPS+ IL-1Ra | 47.0 ± 1.2 | 48.5 ± 1.4 | 49.6 ± 1.0* | 49.3 ± 0.8 | 50.2 ± 1.0* | 50.8 ± 1.1* | 48.8 ± 0.8 | 48.3 ± 1.0 | 48.4 ± 0.7 | 48.1 ± 1.2 | 49.2 ± 0.7 |
PaO2 | |||||||||||
 Saline | 23.9 ± 1.2 | 23.8 ± 0.9 | 23.3 ± 1.5 | 24.2 ± 1.1 | 23.6 ± 0.8 | 25.2 ± 0.9 | 22.5 ± 1.5 | 24.3 ± 1.1 | 24.0 ± 1.4 | 24.2 ± 1.3 | 23.9 ± 0.8 |
 LPS | 22.1 ± 1.0 | 22.8 ± 0.8 | 19.2 ± 0.6* | 22.9 ± 1.2 | 21.1 ± 1.2 | 20.1 ± 1.3* | 22.8 ± 1.1 | 21.6 ± 1.3 | 20.8 ± 0.6* | 23.5 ± 1.4 | 23.1 ± 0.7 |
 LPS+ IL-1Ra | 21.3 ± 0.5 | 20.0 ± 0.6* | 17.8 ± 0.3* | 19.3 ± 0.9* | 17.8 ± 1.2* | 16.7 ± 1.0* | 20.8 ± 0.9 | 19.0 ± 1.0 | 18.3 ± 0.7* | 20.7 ± 1.0 | 21.2 ± 1.0 |
sO2 | |||||||||||
 Saline | 66 ± 2 | 68 ± 2 | 65 ± 3 | 65 ± 2 | 66 ± 2 | 69 ± 2 | 64 ± 3 | 68 ± 2 | 66 ± 2 | 65 ± 2 | 65 ± 2 |
 LPS | 62 ± 3 | 59 ± 3* | 47 ± 2* | 59 ± 3 | 50 ± 4* | 48 ± 4* | 61 ± 3 | 56 ± 3* | 57 ± 2* | 65 ± 2 | 65 ± 3 |
 LPS+ IL-1Ra | 64 ± 1 | 57 ± 3* | 51 ± 2* | 56 ± 3 | 50 ± 4* | 48 ± 3* | 62 ± 2 | 55 ± 3* | 53 ± 2* | 63 ± 3 | 61 ± 2 |
Glucose | |||||||||||
 Saline | 0.9 ± 0.0 | 0.9 ± 0.0 | 0.9 ± 0.0 | 0.9 ± 0.0 | 0.9 ± 0.0 | 0.9 ± 0.0 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.0 | 0.9 ± 0.0 |
 LPS | 0.9 ± 0.1 | 1.1 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.0 | 0.8 ± 0.0 | 0.9 ± 0.2 | 1.0 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.0 | 1.1 ± 0.2 | 0.9 ± 0.1 |
 LPS+ IL-1Ra | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 |
Lactate | |||||||||||
 Saline | 1.7 ± 0.2 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.2 | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.5 ± 0.1 |
 LPS | 1.7 ± 0.1 | 3.1 ± 0.3* | 4.0 ± 0.4* | 1.5 ± 0.1 | 2.3 ±0.1* | 1.9 ± 0.2 | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 |
 LPS+ IL-1Ra | 1.6 ± 0.1 | 2.9 ± 0.4* | 4.4 ± 0.9* | 1.5 ± 0.2 | 2.1 ± 0.4 | 2.1 ± 0.4 | 1.2 ± 0.1 | 1.5 ± 0.1 | 1.3 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 |