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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes

Fig. 4

P2X4R blockage promoted the phenotype of microglia from pro-inflammatory into anti-inflammatory after ICH. A–C Immunostaining for CD16/32+Iba1+/Iba1+ and Arg-1+Iba1+/Iba1+ in ICH + vehicle and ICH + 5-BDBD groups after ICH day 3 (n = 5 per group). D–F Immunostaining for CD16/32+Iba1+/Iba1+ and Arg-1+Iba1+/Iba1+ in ICH + vehicle and ICH + 5-BDBD groups after ICH day 7 (n = 5 per group). G, H Levels of CD16/32 and Arg-1 mRNA transcription were examined by qPCR in the sham, vehicle, and 5-BDBD groups after ICH day 3 (n = 3 per group). I, J Relative mRNA expression of CD16/32 and Arg-1 were examined by qPCR in the sham, vehicle, and 5-BDBD groups after ICH day 7 (n = 3 per group). Data are expressed as the means ± SEM. *P < 0.05. **P < 0.01. ***P < 0.001 vs. ICH + vehicle group. #P < 0.05. ##P < 0.01. ###P < 0.001 vs. ICH + 5-BDBD group. Scale bar = 100 μm

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