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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes

Fig. 5

P2X4R inhibition increased BNDF production in microglia after ICH. A, B BNDF immunostaining in the ICH + vehicle and ICH + 5-BDBD groups after ICH day 3 with quantification. (n = 5 per group). C, D Immunostaining for BDNF+Iba-1+/Iba-1+ in the ICH + vehicle and ICH + 5-BDBD groups after ICH day 7 (n = 5 per group). E, F Western blots show the protein expression of BDNF in the peri-hematoma region with quantification after ICH day 7 (n = 5 per group). Data are expressed as the means ± SEM. *P < 0.05. **P < 0.01. ***P < 0.001 vs. ICH + vehicle group. #P < 0.05. ##P < 0.01. ###P < 0.001 vs. ICH + 5-BDBD group. Scale bar = 100 μm

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