Fig. 7

The blockage of TrkB reversed the treatment effect of inhibition P2X4R on white matter injury after ICH. A and B Representative western blot and quantitative analyses of the protein levels of MBP 3 days after ICH (n = 5 per group). C and D Representative western blot and quantitative analyses of the protein levels of MBP 7 days after ICH (n = 5 per group). E and F Immunostaining for NF200 and MBP in the peri-hematomal region in the ICH + 5-BDBD and ICH + 5-BDBD + ANA-12 groups 3 days and 7 days after ICH. G and H The mean fluorescence densities of MBP in the ICH + 5-BDBD and ICH + 5-BDBD + ANA-12 groups 3 days and 7 days after ICH (n = 5 per group). Data are expressed as the means ± SEM. *P < 0.05. **P < 0.01. ***P < 0.001 vs. ICH + 5-BDBD group. ^#P < 0.05. ^##P < 0.01. ^###P < 0.001 vs. ICH + 5-BDBD + ANA-12 group. Scale bar = 100 μm