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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Inhibition of P2X4R attenuates white matter injury in mice after intracerebral hemorrhage by regulating microglial phenotypes

Fig. 9

Schematic mechanism of the regulation of microglia P2X4R in neuroinflammation and white matter injury in ICH. The level of P2X4R was upregulated after ICH, leading to the phenotype of microglial polarization into pro-inflammatory. The pharmacological inhibition of P2X4R promoted transformation on microglial phenotypes into anti-inflammatory phenotype and the generation of brain-derived neurotrophic factor, and alleviated white matter injury induced by ICH through the BDNF/TrkB pathway (created with BioRender.com)

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Journal of Neuroinflammation

ISSN: 1742-2094