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Table 4 Proinflammatory genes significantly decreased in the brain of PLX5622-treated relative to untreated mice after 6 h of exposure to TLR agonists

From: Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia

PLX5622-treated (n = 7) relative to Untreated exposed to LPS (n = 7) PLX5622-treated (n = 7) relative to Untreated exposed to IMQ (n = 7) PLX5622-treated (n = 6) relative to Untreated exposed to CpG-ODN 1585 (n = 6)
Gene FC P value Gene FC P value Gene FC P value
Ccl20 − 11.1 5.1E-03 Cxcl10 − 18.6 9.9E-05 Ccl20 − 160.8 4.4E-06
Ccl9 − 8.8 6.8E-05 Ccl3 − 15.1 4.4E-06 Ccl3 − 14.1 7.5E-07
Ccl12 − 7.4 3.1E-04 Tnf − 14.2 2.9E-04 Ccl8 − 9.4 7.4E-05
Il1a − 6.5 3.7E-04 Ccl20 − 12.9 4.8E-03 Ccl4 − 9.1 1.1E-06
Pf4 − 6.2 8.9E-06 Ccl4 − 10.4 2.6E-06 Ccr5 − 9.0 8.1E-05
Il1rn − 5.1 3.7E-04 Ccl8 − 9.6 5.0E-04 Il1a − 8.1 4.9E-06
Ccr3 − 5.1 2.1E-03 Cxcl11 − 9.4 5.6E-04 Ccl12 − 8.0 3.9E-06
Ccl3 − 5.1 3.2E-04 Pf4 − 9.2 5.0E-06 Cxcl5 − 7.7 1.8E-05
Ccl4 − 5.1 7.5E-04 Ccl12 − 9.0 5.1E-05 Ccl9 − 6.9 1.4E-04
Ccl8 − 5.0 1.2E-02 Ccl2 − 8.1 1.3E-03 Tnf − 6.8 7.1E-06
Ccr5 − 4.9 1.0E-04 Il1rn − 7.6 6.0E-05 Pf4 − 6.5 7.3E-06
Il27 − 3.2 3.3E-02 Ccl7 − 6.9 2.9E-04 Ccr3 − 6.2 3.6E-04
Ccl5 − 3.0 6.1E-03 Cxcl13 − 6.0 5.5E-03 Csf3 − 6.1 3.4E-07
Il1b − 2.6 3.2E-02 Ccr5 − 5.3 3.3E-05 Il1rn − 6.0 1.2E-05
Ifng − 2.2 4.5E-02 Ccl9 − 4.8 2.4E-03 Ccl5 − 5.5 1.3E-06
Tnfsf10 − 2.1 1.5E-02 Il1b − 4.7 2.4E-02 Cxcl1 − 5.4 5.9E-04
Ccl6 − 4.7 1.4E-04 Tnfsf11 − 5.2 3.7E-03
Ccl5 − 4.4 8.6E-05 Ccl6 − 5.2 1.8E-04
Il1a − 4.0 5.8E-03 Ccr1 − 4.5 1.8E-04
Ccr2 − 4.0 2.0E-02 Cxcr2 − 4.4 2.5E-03
Cxcl1 − 3.9 5.1E-02 Il27 − 4.3 1.2E-02
Csf3 − 3.6 9.0E-03 Cxcl11 − 4.1 3.2E-04
Ccr1 − 3.5 6.8E-03 Ccl22 − 3.4 1.6E-06
Il27 − 3.4 5.4E-03 Ccl11 − 3.3 2.6E-05
Ccr3 − 3.4 1.6E-04 Cxcl10 − 3.3 1.7E-06
Osm − 3.3 1.2E-02 Cxcl9 − 3.3 2.8E-02
Tnfsf10 − 3.2 2.9E-03 Il2rg − 2.9 3.9E-05
Ccl11 − 3.2 8.8E-04 Il1b − 2.8 8.7E-03
Cxcl9 − 2.7 3.7E-02 Osm − 2.7 1.1E-02
Il10ra − 2.3 1.9E-03 Tnfsf10 − 2.6 8.7E-06
Ccl7 − 2.4 5.7E-05
Il6ra − 2.2 5.6E-04
Il10ra − 2.1 2.8E-03
Ccl2 − 2.0 1.3E-03
  1. n is the number of independent mouse RNA samples tested. FC is fold change in gene expression as indicated. P values are calculated using the student t test on the Delta CT. All changes reached our criteria of statistical significance where the FC is less than 2.0-fold with a P value ≤ 5.0E-02