Table 5 TLR signaling pathway associated genes significantly altered in the brain of untreated mice after 6 h of exposure to TLR agonists relative to PBS-treated control mice (n = 3)

Cxcl10

500.5

< 1.0E-10

Cxcl10

182.7

< 1.0E-10

Cxcl10

873.3

< 1.0E-10

Ccl2

110.3

< 1.0E-10

Ccl2

28.6

< 1.0E-10

Ccl2

182.9

< 1.0E-10

Il6

65.8

< 1.0E-10

Tnf

14.0

< 1.0E-10

Il6

108.0

< 1.0E-10

Csf3

51.2

< 1.0E-10

Il6

10.8

< 1.0E-10

Tnf

72.9

< 1.0E-10

Il1b

49.5

< 1.0E-10

Tlr2

4.2

2.0E-07

Il1b

69.7

< 1.0E-10

Tnf

42.0

< 1.0E-10

Il1b

3.8

1.1E-06

Clec4e

68.2

< 1.0E-10

Clec4e

29.0

< 1.0E-10

Eif2ak2

3.3

1.4E-05

Csf3

32.5

< 1.0E-10

Il1a

17.1

< 1.0E-10

Irf1

2.6

4.0E-04

Tlr2

21.0

< 1.0E-10

Tlr2

16.4

< 1.0E-10

Csf3

2.6

4.8E-04

Cd14

12.6

< 1.0E-10

Cd14

11.9

< 1.0E-10

Tlr1

2.5

6.4E-04

Il1a

10.6

< 1.0E-10

Tlr1

7.1

< 1.0E-10

Il1a

2.2

3.3E-03

Il10

7.6

2.1E-09

Il10

6.8

< 1.0E-10

Myd88

2.1

5.8E-03

Tlr1

6.9

1.1E-08

Nfkbia

5.5

1.5E-09

Cd14

2.1

5.8E-03

Eif2ak2

6.0

9.1E-08

Eif2ak2

4.3

2.1E-07

Ifnb1

− 4.4

7.9E-08

Irf1

5.8

1.7E-07

Myd88

4.1

4.6E-07

Csf2

− 82.5

< 1.0E-10

Ifnb1

5.5

3.7E-07

Tnfaip3

4.0

8.6E-07

Myd88

4.9

1.9E-06

Irf1

3.8

1.4E-06

Nfkbia

4.4

8.0E-06

Cd86

3.7

2.3E-06

Tnfaip3

3.7

8.2E-05

Cd80

3.1

3.8E-05

Tlr3

3.0

8.9E-04

Nfkb2

2.7

3.1E-04

Tlr8

3.0

9.6E-04

Ptgs2

2.7

3.1E-04

Cd80

2.8

2.0E-03

Ifng

2.6

7.2E-04

Nfkb2

2.8

2.1E-03

Tnfrsf1a

2.4

1.5E-03

Cd86

2.6

4.7E-03

Ripk2

2.3

2.0E-03

Ripk2

2.5

5.7E-03

Cebpb

2.3

2.8E-03

Casp8

2.5

5.7E-03

Il1r1

2.1

7.2E-03

Tnfrsf1a

2.5

6.4E-03

Tlr3

2.1

6.7E-03

Ptgs2

2.4

7.3E-03

Pglyrp1

2.0

9.7E-03

Tlr6

2.3

1.0E-02

Fos

− 2.0

9.7E-03

Muc13

2.0

3.1E-02

Ifnb1

− 3.1

4.7E-05

Nfkbil1

− 2.1

2.5E-02

Csf2

− 49.4

< 1.0E-10

Csf2

− 43.7

< 1.0E-10