|
LPS (n = 4)
|
IMQ (n = 4)
|
CpG-ODN 1585 (n = 3)
|
|---|
|
Gene
|
FC
|
P value
|
Gene
|
FC
|
P value
|
Gene
|
FC
|
P value
|
|---|
|
Cxcl10
|
500.5
|
< 1.0E-10
|
Cxcl10
|
182.7
|
< 1.0E-10
|
Cxcl10
|
873.3
|
< 1.0E-10
|
|
Ccl2
|
110.3
|
< 1.0E-10
|
Ccl2
|
28.6
|
< 1.0E-10
|
Ccl2
|
182.9
|
< 1.0E-10
|
|
Il6
|
65.8
|
< 1.0E-10
|
Tnf
|
14.0
|
< 1.0E-10
|
Il6
|
108.0
|
< 1.0E-10
|
|
Csf3
|
51.2
|
< 1.0E-10
|
Il6
|
10.8
|
< 1.0E-10
|
Tnf
|
72.9
|
< 1.0E-10
|
|
Il1b
|
49.5
|
< 1.0E-10
|
Tlr2
|
4.2
|
2.0E-07
|
Il1b
|
69.7
|
< 1.0E-10
|
|
Tnf
|
42.0
|
< 1.0E-10
|
Il1b
|
3.8
|
1.1E-06
|
Clec4e
|
68.2
|
< 1.0E-10
|
|
Clec4e
|
29.0
|
< 1.0E-10
|
Eif2ak2
|
3.3
|
1.4E-05
|
Csf3
|
32.5
|
< 1.0E-10
|
|
Il1a
|
17.1
|
< 1.0E-10
|
Irf1
|
2.6
|
4.0E-04
|
Tlr2
|
21.0
|
< 1.0E-10
|
|
Tlr2
|
16.4
|
< 1.0E-10
|
Csf3
|
2.6
|
4.8E-04
|
Cd14
|
12.6
|
< 1.0E-10
|
|
Cd14
|
11.9
|
< 1.0E-10
|
Tlr1
|
2.5
|
6.4E-04
|
Il1a
|
10.6
|
< 1.0E-10
|
|
Tlr1
|
7.1
|
< 1.0E-10
|
Il1a
|
2.2
|
3.3E-03
|
Il10
|
7.6
|
2.1E-09
|
|
Il10
|
6.8
|
< 1.0E-10
|
Myd88
|
2.1
|
5.8E-03
|
Tlr1
|
6.9
|
1.1E-08
|
|
Nfkbia
|
5.5
|
1.5E-09
|
Cd14
|
2.1
|
5.8E-03
|
Eif2ak2
|
6.0
|
9.1E-08
|
|
Eif2ak2
|
4.3
|
2.1E-07
|
Ifnb1
|
− 4.4
|
7.9E-08
|
Irf1
|
5.8
|
1.7E-07
|
|
Myd88
|
4.1
|
4.6E-07
|
Csf2
|
− 82.5
|
< 1.0E-10
|
Ifnb1
|
5.5
|
3.7E-07
|
|
Tnfaip3
|
4.0
|
8.6E-07
| | | |
Myd88
|
4.9
|
1.9E-06
|
|
Irf1
|
3.8
|
1.4E-06
| | | |
Nfkbia
|
4.4
|
8.0E-06
|
|
Cd86
|
3.7
|
2.3E-06
| | | |
Tnfaip3
|
3.7
|
8.2E-05
|
|
Cd80
|
3.1
|
3.8E-05
| | | |
Tlr3
|
3.0
|
8.9E-04
|
|
Nfkb2
|
2.7
|
3.1E-04
| | | |
Tlr8
|
3.0
|
9.6E-04
|
|
Ptgs2
|
2.7
|
3.1E-04
| | | |
Cd80
|
2.8
|
2.0E-03
|
|
Ifng
|
2.6
|
7.2E-04
| | | |
Nfkb2
|
2.8
|
2.1E-03
|
|
Tnfrsf1a
|
2.4
|
1.5E-03
| | | |
Cd86
|
2.6
|
4.7E-03
|
|
Ripk2
|
2.3
|
2.0E-03
| | | |
Ripk2
|
2.5
|
5.7E-03
|
|
Cebpb
|
2.3
|
2.8E-03
| | | |
Casp8
|
2.5
|
5.7E-03
|
|
Il1r1
|
2.1
|
7.2E-03
| | | |
Tnfrsf1a
|
2.5
|
6.4E-03
|
|
Tlr3
|
2.1
|
6.7E-03
| | | |
Ptgs2
|
2.4
|
7.3E-03
|
|
Pglyrp1
|
2.0
|
9.7E-03
| | | |
Tlr6
|
2.3
|
1.0E-02
|
|
Fos
|
− 2.0
|
9.7E-03
| | | |
Muc13
|
2.0
|
3.1E-02
|
|
Ifnb1
|
− 3.1
|
4.7E-05
| | | |
Nfkbil1
|
− 2.1
|
2.5E-02
|
|
Csf2
|
− 49.4
|
< 1.0E-10
| | | |
Csf2
|
− 43.7
|
< 1.0E-10
|
- n is the number of independent mouse RNA samples tested. Fold change (FC) relative to PBS treated mice. P values are calculated using the student t-test on the Delta CT. All changes reached our criteria of statistical significance where the FC is greater or less than 2-fold with a P value ≤ 5.0E-02
