Fig. 2

Galantamine prevents AIE-induced deficits in hippocampal neurogenesis. (A) Photomicrograph of DCX+IR in each respective group. Clockwise, from the upper left corner: CON-Veh, CON-Gal, AIE-Gal, AIE-Veh. (B) AIE decreased DCX+IR relative to CON rats in vehicle-treated groups. Galantamine restored DCX+IR to control levels in AIE-treated rats. This suggests that cholinesterase inhibition blocks the long-term effects of AIE on neurogenesis within the dentate gyrus. DCX+IR was quantified as pixels/mm² with results expressed as mean ± standard error of the mean (SEM). Scale bars indicate 200 μM. For each identified comparison, *p < 0.05