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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease

Fig. 2

Single-cell level glucose metabolic features in the hippocampus of the AD mouse model. A RNA-sequencing data from a total of 5812 cells from 5xFAD mice (2-, 6-, and 9-month-old) and WT were analyzed. The t-distributed stochastic neighborhood embedding (t-SNE) map showed the different distribution of cells according to the progression of 5xFAD. B Each cell was clustered and named according to markers. C To analyze glucose metabolic features, the gene module was scored by gene sets of glycolysis, oxidative phosphorylation (OXPHOS), and glucose transporters (GLUTs). The enrichment score of each cell cluster derived from different groups was compared. Accordingly, a cluster, ‘microglia 1’ showed significantly different enrichment scores of glycolysis, OXPHOS, and GLUTs. Another microglia cluster, ‘microglia 2’, also showed significantly different enrichment scores of glycolysis and OXPHOS. (ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)

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