Fig. 3
From: Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease
Reconstitution of glucose metabolism features of hippocampal microglia in the AD mouse model. A The t-SNE map represents the hippocampal microglia of different mouse groups. B Four different subtypes of hippocampal microglia were identified. The distribution pattern of microglial subtypes was changed according to mouse groups. C The proportion of subtypes of hippocampal microglia changed according to the age of 5xFAD mice. The 6-month-old and 9-month-old mice showed relatively more hippocampal microglia subtype 2. D The glucose metabolic features of microglial subtypes are represented. The enrichment score of GLUTs showed a different distribution pattern than glycolysis and OXPHOS enrichment scores. E Glucose metabolism features of the hippocampal microglial subtypes were different. Glycolysis and OXPHOS enrichment scores were lower in ‘Subtype 2’, while GLUT enrichment score was higher in ‘Subtype 2’ than other subtypes