Fig. 5
From: Hippocampal glucose uptake as a surrogate of metabolic change of microglia in Alzheimer’s disease
Hippocampal FDG uptake and CSF biomarkers for microglia-mediated inflammation. Hippocampal FDG uptake showed a trend of positive correlation with CSF sTREM2. A The left hippocampal FDG uptake showed a significant positive correlation with sTREM2 (r = 0.23, p = 0.03). B The right hippocampal FDG uptake showed a weak positive correlation with CSF sTREM2 (r = 0.14, p = 0.19), which did not reach statistical significance. C Hippocampal FDG uptake in both hippocampi also showed a weak positive correlation with CSF sTREM2 (r = 0.18, p = 0.08). D–F A subgroup, MCI showed a positive correlation between sTREM2 and hippocampal FDG uptake (r = 0.38, p = 0.008 for the left hippocampus; r = 0.25, p = 0.09 for the right hippocampus; r = 0.32, p = 0.026 for both hippocampi). G Two representative cases of MCI patients who showed different FDG uptake patterns. An MCI patient with relatively high CSF sTREM2 had increased FDG uptake in the medial temporal lobes, while another MCI patient with relatively low CSF sTREM2 had a hypometabolic pattern in the medial temporal lobe