Cytokines | Time | Non-pain | Compared with baseline | Pain | Compared with baseline | ||
---|---|---|---|---|---|---|---|
Mean ± SD | t | P | Mean ± SD | t | P | ||
ITAC | Day 13 | 1.22 ± 0.25 | − 0.857 | 1.000 | 1.22 ± 0.26 | − 0.762 | 1.000 |
Day 26 | 1.16 ± 0.24 | 0.690 | 1.000 | 1.16 ± 0.23 | 0.571 | 1.000 | |
GMCSF | Day 13 | 1.68 ± 0.31 | − 1.109 | 0.788 | 1.79 ± 0.38 | 0.891 | 1.000 |
Day 26 | 1.62 ± 0.39 | 0.326 | 1.000 | 1.59 ± 0.37 | 5.109 | < 0.001 | |
Fractalkine | Day 13 | 2.52 ± 0.24 | − 1.452 | 0.464 | 2.57 ± 0.26 | 0.476 | 1.000 |
Day 26 | 2.44 ± 0.35 | 0.381 | 1.000 | 2.41 ± 0.28 | 4.381 | < 0.001 | |
IFN-γ | Day 13 | 1.00 ± 0.25 | − 0.426 | 1.000 | 1.06 ± 0.26 | − 0.085 | 1.000 |
Day 26 | 0.96 ± 0.30 | 0.426 | 1.000 | 0.91 ± 0.26 | 3.710 | 0.005 | |
IL-10 | Day 13 | 1.22 ± 0.46 | − 0.947 | 1.000 | 1.31 ± 0.51 | 0.456 | 1.000 |
Day 26 | 1.08 ± 0.52 | 1.632 | 0.314 | 1.10 ± 0.54 | 4.053 | < 0.001 | |
MIP-3α | Day 13 | 1.12 ± 0.31 | − 0.836 | 1.000 | 1.19 ± 0.27 | 0.091 | 1.000 |
Day 26 | 1.04 ± 0.45 | 0.618 | 1.000 | 1.04 ± 0.35 | 2.964 | 0.011 | |
IL-12P70 | Day 13 | 0.46 ± 0.35 | − 0.974 | 1.000 | 0.52 ± 0.33 | 0.051 | 1.000 |
Day 26 | 0.39 ± 0.42 | 0.897 | 1.000 | 0.39 ± 0.37 | 3.385 | 0.003 | |
IL-13 | Day 13 | 0.52 ± 0.48 | 0.843 | 1.000 | 0.63 ± 0.32 | − 0.098 | 1.000 |
Day 26 | 0.52 ± 0.47 | 0.647 | 1.000 | 0.55 ± 0.48 | 1.588 | 0.338 | |
IL-17α | Day 13 | 0.96 ± 0.30 | − 0.333 | 1.000 | 1.06 ± 0.31 | − 0.311 | 1.000 |
Day 26 | 0.89 ± 0.42 | 1.267 | 0.615 | 0.88 ± 0.36 | 3.711 | 0.001 | |
IL-1β | Day 13 | 0.17 ± 0.36 | − 0.769 | 1.000 | 0.23 ± 0.39 | 1.635 | 0.313 |
Day 26 | 0.09 ± 0.43 | 0.808 | 1.000 | 0.10 ± 0.39 | 4.288 | < 0.001 | |
IL-2 | Day 13 | 0.59 ± 0.35 | − 0.442 | 1.000 | 0.66 ± 0.40 | 0.186 | 1.000 |
Day 26 | 0.49 ± 0.43 | 1.767 | 0.229 | 0.50 ± 0.40 | 0.395 | < 0.001 | |
IL-4 | Day 13 | 1.46 ± 0.29 | − 0.024 | 1.000 | 1.56 ± 0.25 | 0.098 | 1.000 |
Day 26 | 1.44 ± 0.37 | 0.463 | 1.000 | 1.45 ± 0.24 | 2.951 | 0.012 | |
IL-23 | Day 13 | 2.37 ± 0.46 | − 0.736 | 1.000 | 2.52 ± 0.45 | 0.264 | 1.000 |
Day 26 | 2.23 ± 0.53 | 1.887 | 0.184 | 2.32 ± 0.50 | 3.981 | < 0.001 | |
IL-5 | Day 13 | 0.74 ± 0.40 | − 0.637 | 1.000 | 0.71 ± 0.41 | 2.218 | 0.087 |
Day 26 | 0.66 ± 0.46 | 0.909 | 1.000 | 0.64 ± 0.41 | 3.473 | 0.002 | |
IL-6 | Day 13 | 0.19 ± 0.27 | − 1.750 | 0.246 | 0.24 ± 0.19 | 1.850 | 0.043 |
Day 26 | 0.14 ± 0.50 | − 0.900 | 1.000 | 0.14 ± 0.36 | 3.600 | 0.001 | |
IL-7 | Day 13 | 0.97 ± 0.35 | − 0.727 | 1.000 | 1.05 ± 0.32 | 0.114 | 1.000 |
Day 26 | 0.88 ± 0.47 | 1.318 | 0.548 | 0.90 ± 0.32 | 3.705 | 0.001 | |
IL-8 | Day 13 | 0.49 ± 0.27 | − 1.298 | 0.576 | 0.50 ± 0.28 | − 1.170 | 0.738 |
Day 26 | 0.38 ± 0.37 | 1.043 | 0.895 | 0.39 ± 0.30 | 1.170 | 0.738 | |
MIP-1β | Day 13 | 1.07 ± 0.30 | 1.548 | 0.364 | 1.10 ± 0.34 | 0.452 | 1.000 |
Day 26 | 1.07 ± 0.24 | 1.581 | 0.329 | 1.03 ± 0.36 | 2.774 | 0.016 | |
TNF-α | Day 13 | 0.59 ± 0.17 | 4.341 | < 0.001 | 0.67 ± 0.23 | 3.024 | 0.009 |
Day 26 | 0.49 ± 0.25 | 6.585 | < 0.001 | 0.52 ± 0.22 | 6.439 | < 0.001 |