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Table 2 Comparison of inflammatory cytokine levels between post-infusion and baseline

From: Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine

Cytokines

Time

Non-pain

Compared with baseline

Pain

Compared with baseline

Mean ± SD

t

P

Mean ± SD

t

P

ITAC

Day 13

1.22 ± 0.25

− 0.857

1.000

1.22 ± 0.26

− 0.762

1.000

Day 26

1.16 ± 0.24

0.690

1.000

1.16 ± 0.23

0.571

1.000

GMCSF

Day 13

1.68 ± 0.31

− 1.109

0.788

1.79 ± 0.38

0.891

1.000

Day 26

1.62 ± 0.39

0.326

1.000

1.59 ± 0.37

5.109

< 0.001

Fractalkine

Day 13

2.52 ± 0.24

− 1.452

0.464

2.57 ± 0.26

0.476

1.000

Day 26

2.44 ± 0.35

0.381

1.000

2.41 ± 0.28

4.381

< 0.001

IFN-γ

Day 13

1.00 ± 0.25

− 0.426

1.000

1.06 ± 0.26

− 0.085

1.000

Day 26

0.96 ± 0.30

0.426

1.000

0.91 ± 0.26

3.710

0.005

IL-10

Day 13

1.22 ± 0.46

− 0.947

1.000

1.31 ± 0.51

0.456

1.000

Day 26

1.08 ± 0.52

1.632

0.314

1.10 ± 0.54

4.053

< 0.001

MIP-3α

Day 13

1.12 ± 0.31

− 0.836

1.000

1.19 ± 0.27

0.091

1.000

Day 26

1.04 ± 0.45

0.618

1.000

1.04 ± 0.35

2.964

0.011

IL-12P70

Day 13

0.46 ± 0.35

− 0.974

1.000

0.52 ± 0.33

0.051

1.000

Day 26

0.39 ± 0.42

0.897

1.000

0.39 ± 0.37

3.385

0.003

IL-13

Day 13

0.52 ± 0.48

0.843

1.000

0.63 ± 0.32

− 0.098

1.000

Day 26

0.52 ± 0.47

0.647

1.000

0.55 ± 0.48

1.588

0.338

IL-17α

Day 13

0.96 ± 0.30

− 0.333

1.000

1.06 ± 0.31

− 0.311

1.000

Day 26

0.89 ± 0.42

1.267

0.615

0.88 ± 0.36

3.711

0.001

IL-1β

Day 13

0.17 ± 0.36

− 0.769

1.000

0.23 ± 0.39

1.635

0.313

Day 26

0.09 ± 0.43

0.808

1.000

0.10 ± 0.39

4.288

< 0.001

IL-2

Day 13

0.59 ± 0.35

− 0.442

1.000

0.66 ± 0.40

0.186

1.000

Day 26

0.49 ± 0.43

1.767

0.229

0.50 ± 0.40

0.395

< 0.001

IL-4

Day 13

1.46 ± 0.29

− 0.024

1.000

1.56 ± 0.25

0.098

1.000

Day 26

1.44 ± 0.37

0.463

1.000

1.45 ± 0.24

2.951

0.012

IL-23

Day 13

2.37 ± 0.46

− 0.736

1.000

2.52 ± 0.45

0.264

1.000

Day 26

2.23 ± 0.53

1.887

0.184

2.32 ± 0.50

3.981

< 0.001

IL-5

Day 13

0.74 ± 0.40

− 0.637

1.000

0.71 ± 0.41

2.218

0.087

Day 26

0.66 ± 0.46

0.909

1.000

0.64 ± 0.41

3.473

0.002

IL-6

Day 13

0.19 ± 0.27

− 1.750

0.246

0.24 ± 0.19

1.850

0.043

Day 26

0.14 ± 0.50

− 0.900

1.000

0.14 ± 0.36

3.600

0.001

IL-7

Day 13

0.97 ± 0.35

− 0.727

1.000

1.05 ± 0.32

0.114

1.000

Day 26

0.88 ± 0.47

1.318

0.548

0.90 ± 0.32

3.705

0.001

IL-8

Day 13

0.49 ± 0.27

− 1.298

0.576

0.50 ± 0.28

− 1.170

0.738

Day 26

0.38 ± 0.37

1.043

0.895

0.39 ± 0.30

1.170

0.738

MIP-1β

Day 13

1.07 ± 0.30

1.548

0.364

1.10 ± 0.34

0.452

1.000

Day 26

1.07 ± 0.24

1.581

0.329

1.03 ± 0.36

2.774

0.016

TNF-α

Day 13

0.59 ± 0.17

4.341

< 0.001

0.67 ± 0.23

3.024

0.009

Day 26

0.49 ± 0.25

6.585

< 0.001

0.52 ± 0.22

6.439

< 0.001

  1. Abbreviations: ITAC, interferon-inducible T cell alpha chemoattractant; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; MIP, macrophage inflammatory protein; TNF, tumor necrosis factor