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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice

Fig. 2

Hippocampal MD2 expression is increased after anesthesia and surgery in aged mice. A Expression of hippocampal MD2 at the indicated timepoint after the operation (F(3,20) = 4.986, p = 0.0096. p = 0.0282, Sham vs. 24 h; p = 0.0159, Sham vs. 72 h; n = 6 each). β-Actin was used as a loading control. B Representative immunofluorescence images of MD2 in neurons, astroglia, and microglia in the hippocampus. C Representative immunofluorescence images and quantification of neuronal MD2 in the Sham group and Surgery group in the hippocampus (p = 0.0470, Sham vs. Surgery; n = 3 each). Arrows in the figures indicate the co-localization of two fluorescent substances. The data are presented as the mean ± SD; * p < 0.05, compared with the Sham group. Scale bar = 25 μm

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