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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice

Fig. 4

Tat-CIRP-CMA alleviates cognitive decline caused by anesthesia and surgery. A Expression of MD2 after TCM treatment in the cultured primary neurons (p = 0.0272; n = 3 each). Tubulin was used as a loading control. B Distribution of Cy7NHS or Cy7-TCM in the brain at 5 min, 10 min, 20 min, and 30 min after peripheral administration (5 min p = 0.0231, 10 min p = 0.0375, 20 min p = 0.0051, 30 min p = 0.0059, Cy7NHS vs. Cy7-TCM; n = 4 each). C Distribution of Cy7NHS or Cy7-TCM in the hippocampus (p = 0.0366; n = 3 each). Scale bar = 100 μm. D Timeline of the TCM treatment. E Representative tracks and heat maps of mice in the Barnes maze. F Mean latency in the training phase (F(1,13) = 6.442, p = 0.0247. post hoc: day 5 p = 0.8663, day 6 p = 0.6776, day 7 p = 0.9999, day 8 p = 0.9999). G Time spent in the target zone in the probe phase (p = 0.0476). H Average speed in the probe phase (p = 0.7557). I Total distance in the probe phase (p = 0.7820). The data are presented as the mean ± SD; * p < 0.05, compared with the Saline group, the Surgery + Saline group or the Cy7NHS group; ** p < 0.01, compared with the Cy7NHS group. n = 8 Surgery + Saline, n = 7 Surgery + TCM

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