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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: MD2 contributes to the pathogenesis of perioperative neurocognitive disorder via the regulation of α5GABAA receptors in aged mice

Fig. 6

Antagonizing α5GABAARs reverses anesthesia and surgery-induced cognitive deficits. A Timeline of the L-655,708 treatment. B Representative tracks and heat maps. C Mean latency in the training phase (F(1,13) = 6.187, p = 0.0272. post hoc: day 5 p = 0.8236, day 6 p = 0.7998, day 7 p = 0.9996, day 8 p = 0.2488). D Time spent in the target zone in the probe day (p = 0.0062). E Average speed in the probe phase (p = 0.9987). F Total distance in the probe day (p = 0.9843). The data are presented as the mean ± SD; * p < 0.05, ** p < 0.01, compared with the Surgery + Saline group. n = 7 Surgery + Saline, n = 8 Surgery + L-655,708

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