Fig. 7
Activating α5GABAARs abrogates the beneficial effects of Tat-CIRP-CMA against anesthesia and surgery-induced cognitive deficits. A Timeline of the L-838,417 treatment. B Representative track plots and heat maps. C Mean latency in training phase (F(2,20) = 4.909, p = 0.0184. post hoc: p = 0.0286 Surgery + Saline vs. Surgery + TCM, p = 0.0443 Surgery + TCM vs. Surgery + L838,417 + TCM). D Time spent in the target zone in the probe phase (F(2,20) = 5.068, p = 0.0166. post hoc: p = 0.0254 Surgery + Saline vs. Surgery + TCM, p = 0.0422 Surgery + TCM vs. Surgery + L838,417 + TCM). E Average speed in the probe phase (F(2,20) = 0.2299, p = 0.7967. post hoc: p = 0.9377 Surgery + Saline vs. Surgery + TCM, p = 0.7789 Surgery + TCM vs. Surgery + L838,417 + TCM). F Total distance in the probe day (F(2,20) = 0.2515, p = 0.7801. post hoc: p = 0.9479 Surgery + Saline vs. Surgery + TCM, p = 0.7614 Surgery + TCM vs. Surgery + L838,417 + TCM). The data are presented as the mean ± SD; * p < 0.05, compared with the Surgery + Saline group; # p < 0.05, compared with the Surgery + TCM group; n = 8 Surgery + Saline, n = 8 Surgery + TCM, n = 7 Surgery + L838,417 + TCM