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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

Fig. 3

NAD+ reduced CCH-induced neuronal death and microglial activation. A HE staining of cortex and hippocampus CA1 at different magnifications (scale bar = 50 μm or 5 μm). B Representative immunofluorescent staining for Iba1-labeled microglia (red). Nuclei were stained with DAPI (blue). Scale bar = 50 μm. C The mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, iNOS, TNF-α, and COX2) was detected by qRT-PCR. *P < 0.05; **P < 0.01 sham and NAD+ vs. CCH

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Journal of Neuroinflammation

ISSN: 1742-2094