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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

Fig. 5

Exploration of potential mechanisms of NAD+ effects in CCH model. A RNA-seq results showing hierarchical clustering of co-regulated DEGs. B Volcano plotting of DEGs. C The significantly changed genes that were analyzed by KEGG enrichment. D List of enriched GO term on biological process, cellular component, and molecular function. E Western blot analysis of Sirt1, PGC-1α in hippocampus. Data are expressed as mean ± SEM (n = 3). Data are expressed as mean ± SEM (n = 3). *P < 0.05, **P < 0.01, vs. CCH

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Journal of Neuroinflammation

ISSN: 1742-2094