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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

Fig. 8

NAD+ alleviated hypoxia-induced ROS production by promoting the expression of Sirt1/PGC-1α. A Representative image of microglia loaded with ROS indicator DCF-DA (green). B Flow cytometry analysis of ROS production in BV2 microglia. Data are expressed as mean ± SEM (n = 3), *P < 0.05, **P < 0.01 vs. Hyp and Hyp + NC. C Western blot analysis of Sirt1 and PGC-1α. Data are expressed as mean ± SEM (n = 3). *P < 0.05, **P < 0.01 vs. Hyp and Hyp + NC

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